| Day | Date | Time | Location | Visitor | Home |
| Mon | Oct 18/04 (Mon) | 10:00pm | NE | COLTS 20 | PATRIOTS 14 |
| Mon | Oct 18/04 (Mon) | 10:00pm | BUF | JAGUARS | BILLS |
| Mon | Oct 18/04 (Mon) | 10:00pm | CHI | LIONS | BEARS |
| Mon | Oct 18/04 (Mon) | 10:00pm | CLE | RAVENS | BROWNS |
| Mon | Oct 18/04 (Mon) | 10:00pm | STL | CARDINALS | RAMS |
| Mon | Oct 18/04 (Mon) | 10:00pm | MIA | TITANS | DOLPHINS |
| Mon | Oct 18/04 (Mon) | 10:00pm | NO | SEAHAWKS | SAINTS |
| Mon | Oct 18/04 (Mon) | 10:00pm | NYJ | BANGLES | JETS |
| Mon | Oct 18/04 (Mon) | 10:00pm | PIT | RADERS | STEELERS |
| Mon | Oct 18/04 (Mon) | 10:00pm | WAS | BUCKENERS | RESKINDS |
| Mon | Oct 18/04 (Mon) | 10:00pm | HOU | CHARGERS | TEXANS |
| Mon | Oct 18/04 (Mon) | 10:00pm | MIN | COWBOYS | VININGS |
| Mon | Oct 18/04 (Mon) | 10:00pm | PHI | GIANTS | EAGLES |
| Mon | Oct 18/04 (Mon) | 10:00pm | SF | FALCONS | 49ERS |
| Mon | Oct 18/04 (Mon) | 10:00pm | DEN | CHEFITS | BRONCOS |
| Mon | Oct 18/04 (Mon) | 10:00pm | CAR | PACKERS | PANTHERS |