| Date | Time | Location | Visitor | Home |
|---|---|---|---|---|
| Sep 24/21 | 5:00pm | Centoramericano | Hatillo FC 0 | EduSoccer 8 |
| Sep 24/21 | 5:00pm | Centroamericano | Caribe Soccer 2 | Rincon Surfers 1 |
| Sep 24/21 | 6:30pm | Centroamericano | Caribe Soccer 0 | PR Sol 5 |
| Sep 24/21 | 7:00pm | Centroamericano | Coamo FC 1 | Escalanate FC 2 |
| Sep 24/21 | 7:45pm | Centroamericano | PR Sol 4 | Leal Arecibo 2 |
| Sep 24/21 | 9:15pm | Centroamericano | Leal Arecibo 2 | La Rambla 1 2 |
| Sep 25/21 | 9:00am | Cabo Rojo | Academia Futbol Total | EduSoccer1 |
| Sep 25/21 | 9:00am | Cabo Rojo | EduSoccer1 2 | Academia Futbol Total 2 |
| Sep 25/21 | 9:00am | Cabo Rojo | EduSoccer1 | EduSoccer2 |
| Sep 25/21 | 9:00am | Cabo Rojo | Academia Futbol Total 7 | Roberto Cofresi SC 2 |
| Sep 25/21 | 9:40am | Cabo Rojo | EduSoccer2 | EduSoccer3 |
| Sep 25/21 | 10:00am | Cabo Rojo | Roberto Cofresi SC | EduSoccer3 |
| Sep 25/21 | 10:00am | Cabo Rojo | Academia Futbol Total | Roberto Cofresi SC |
| Sep 25/21 | 10:00am | Centroamericano | Legendarios 0 | EduSoccer 2 |
| Sep 25/21 | 10:15am | Cabo Rojo | PR Sol 0 | EduSoccer1 5 |
| Sep 25/21 | 10:50am | Cabo Rojo | EduSoccer1 | EduSoccer2 |
| Sep 25/21 | 11:00am | Cabo Rojo | Academia Futbol Total | Roberto Cofresi SC |
| Sep 25/21 | 11:30am | Cabo Rojo | Academia Futbol Total | EduSoccer3 |
| Sep 25/21 | 11:30am | Cabo Rojo | Roberto Cofresi SC | EduSoccer1 |
| Sep 25/21 | 11:30am | Cabo Rojo | CF Atletico de Anasco 0 | Rincon Surfers 10 |
| Sep 25/21 | 1:00pm | Cabo Rojo | EduSoccer1 | EduSoccer2 |
| Sep 25/21 | 1:15pm | Cabo Rojo | Academia Futbol Total 5 | EduSoccer1 4 |
| Sep 25/21 | 1:30pm | Cabo Rojo | EduSoccer2 | Academia Futbol Total |
| Sep 25/21 | 2:30pm | Cabo Rojo | PR Sol 7 | CF Atletico de Anasco 2 |
| Sep 25/21 | 3:45pm | Cabo Rojo | Rincon Surfers 0 | EduSoccer2 3 |
| Sep 25/21 | 8:00pm | Cabo Rojo | La Rambla 2 1 | Legendarios 3 |
| Oct 1/21 | 6:30pm | Cabo Rojo | Escalanate FC 3 | EduSoccer 1 |
| Oct 1/21 | 8:00pm | Cabo Rojo | Leal Arecibo 1 | EduSoccer 2 |
| Oct 1/21 | 8:00pm | Coamo | Legendarios 0 | Coamo FC 2 |
| Oct 1/21 | 8:00pm | Coamo | La Rambla 1 3 | La Rambla 2 1 |
| Oct 8/21 | 6:30pm | Coamo | EduSoccer 1 | Legendarios 0 |
| Oct 8/21 | 6:30pm | Hatillo | Leal Arecibo 1 | Hatillo FC 0 |
| Oct 8/21 | 6:30pm | Centroamericano | EduSoccer 3 | PR Sol 0 |
| Oct 8/21 | 8:00pm | Hatillo | Rincon Surfers 2 | Leal Arecibo 4 |
| Oct 8/21 | 8:00pm | Centroamericano | Escalante 0 | PR Sol 3 |
| Oct 8/21 | 8:00pm | Coamo | Academia Futbol Total 3 | Legendarios 0 |
| Oct 8/21 | 8:00pm | Coamo | Caribe Soccer 4 | La Rambla 2 1 |
| Oct 8/21 | 8:00pm | Coamo | Coamo FC 3 | La Rambla 1 2 |
| Oct 9/21 | 9:00am | Aguadilla | CF Atletico de Anasco 1 | EduSoccer1 9 |
| Oct 9/21 | 10:15am | Aguadilla | EduSoccer2 4 | Roberto Cofresi SC 0 |
| Oct 9/21 | 11:30am | Aguadilla | Academia Futbol Total 6 | PR Sol 3 |
| Oct 9/21 | 1:15pm | Aguadilla | CF Atletico de Anasco 2 | EduSoccer2 5 |
| Oct 9/21 | 1:45pm | Aguadilla | Roberto Cofresi SC 1 | PR Sol 10 |
| Oct 9/21 | 2:30pm | Aguada | Academia Futbol Total 1 | Rincon Surfers 1 |
| Oct 15/21 | 6:30pm | Hormigueros | La Rambla 2 0 | EduSoccer 10 |
| Oct 15/21 | 6:30pm | Centroamericano | EduSoccer 2 | Academia Futbol Total 2 |
| Oct 15/21 | 6:30pm | Caobos Ponce | Legendarios 1 | Caribe Soccer 4 |
| Oct 15/21 | 7:45pm | Centroamericano | Hatillo FC 1 | Escalante 0 |
| Oct 15/21 | 8:00pm | Hormigueros | La Rambla 1 2 | Rincon Surfers 1 |
| Oct 15/21 | 8:00pm | Caobos Ponce | Legendarios 3 | Escalanate FC 2 |
| Oct 15/21 | 8:00pm | Caobos Ponce | Coamo FC 2 | Caribe Soccer 2 |
| Oct 15/21 | 9:10pm | Centroamericano | EduSoccer 6 | PR Sol 0 |
| Oct 22/21 | 7:30pm | Centroamericano | Caribe Soccer 0 | EduSoccer 7 |
| Oct 22/21 | 8:45pm | Centroamericano | Caribe Soccer 5 | Leal Arecibo 1 |
| Oct 23/21 | 9:00am | Aguadilla | EduSoccer1 11 | EduSoccer2 1 |
| Oct 23/21 | 10:15am | Aguadilla | Academia Futbol Total 7 | CF Atletico de Anasco 0 |
| Oct 23/21 | 11:30am | Aguadilla | Rincon Surfers 4 | Roberto Cofresi SC 0 |
| Oct 23/21 | 12:30pm | Aguada | Academia Futbol Total 8 | EduSoccer2 0 |
| Oct 23/21 | 1:30pm | Aguadilla | EduSoccer1 6 | Roberto Cofresi SC 0 |
| Oct 23/21 | 2:30pm | Aguadilla | PR Sol 3 | Rincon Surfers 3 |
| Oct 24/21 | 9:00am | Centroamericano | Hatillo FC 0 | PR Sol 3 |
| Oct 24/21 | 9:00am | Cabo Rojo | Escalante 0 | Leal Arecibo 0 |
| Oct 24/21 | 10:30am | Centroamericano | Caribe Soccer 1 | EduSoccer 0 |
| Oct 24/21 | 10:30am | Cabo Rojo | La Rambla 2 0 | Leal Arecibo 5 |
| Oct 24/21 | 12:00pm | Cabo Rojo | La Rambla 1 2 | Escalanate FC 1 |
| Oct 24/21 | 12:00pm | Centroamericano | Legendarios 0 | PR Sol 4 |
| Oct 24/21 | 1:30pm | Centroamericano | Coamo FC 5 | Rincon Surfers 0 |
| Oct 24/21 | 1:30pm | Cabo Rojo | Academia Futbol Total 2 | Caribe Soccer 1 |
| Oct 29/21 | 6:30pm | Centroamericano | Caribe Soccer 2 | PR Sol 3 |
| Oct 29/21 | 6:30pm | Cabo Rojo | EduSoccer 4 | Escalante 0 |
| Oct 29/21 | 7:45pm | Centroamericano | Coamo FC 6 | Leal Arecibo 3 |
| Oct 29/21 | 9:15pm | Centroamericano | Leal Arecibo 2 | PR Sol 3 |
| Nov 5/21 | 6:30pm | Centroamericano | Academia Futbol Total 1 | PR Sol 3 |
| Nov 5/21 | 6:45pm | Hatillo | EduSoccer 7 | Leal Arecibo 1 |
| Nov 5/21 | 7:30pm | Fagot | Caribe Soccer 2 | EduSoccer 3 |
| Nov 5/21 | 7:45pm | Centroamericano | Rincon Surfers 0 | Escalanate FC 3 |
| Nov 5/21 | 8:00pm | Hatillo | EduSoccer 4 | Leal Arecibo 0 |
| Nov 5/21 | 9:15pm | Hatillo | Escalante 2 | Hatillo FC 0 |
| Nov 6/21 | 9:00am | Cabo Rojo | CF Atletico de Anasco 3 | Roberto Cofresi SC 5 |
| Nov 6/21 | 10:15am | Cabo Rojo | EduSoccer2 0 | PR Sol 10 |
| Nov 6/21 | 1:15pm | Cabo Rojo | Roberto Cofresi SC 2 | Academia Futbol Total 9 |
| Nov 6/21 | 3:45pm | Cabo Rojo | Rincon Surfers 3 | CF Atletico de Anasco 0 |
| Nov 11/21 | 7:20pm | Coamo | La Rambla 1 3 | Caribe Soccer 1 |
| Nov 12/21 | 6:45pm | Arecibo | Escalante 1 | Leal Arecibo 1 |
| Nov 12/21 | 8:00pm | Arecibo | Escalanate FC 6 | Leal Arecibo 0 |
| Nov 12/21 | 9:15pm | Arecibo | PR Sol 2 | Hatillo FC 1 |
| Nov 13/21 | 10:20am | Coamo | Legendarios 0 | Caribe Soccer 2 |
| Nov 13/21 | 1:30pm | Coamo | Rincon Surfers 0 | Legendarios 3 |
| Nov 19/21 | 6:30pm | Centroamericano | PR Sol 2 | EduSoccer 3 |
| Nov 19/21 | 7:00pm | Arecibo | Hatillo FC 1 | Leal Arecibo 2 |
| Nov 19/21 | 7:45pm | Centroamericano | Legendarios 0 | Academia Futbol Total 6 |
| Nov 19/21 | 7:45pm | Centroamericano | EduSoccer 6 | PR Sol 0 |
| Nov 20/21 | 9:00am | Aguadilla | EduSoccer1 4 | Academia Futbol Total 0 |
| Nov 20/21 | 10:20am | Aguadilla | PR Sol 12 | CF Atletico de Anasco 2 |
| Nov 20/21 | 11:30am | Aguadilla | Rincon Surfers 1 | EduSoccer2 0 |
| Nov 20/21 | 12:45pm | Aguadilla | CF Atletico de Anasco 0 | EduSoccer1 3 |
| Nov 20/21 | 1:40pm | Aguadilla | Academia Futbol Total 1 | PR Sol 5 |
| Nov 20/21 | 1:45pm | Aguadilla | EduSoccer2 9 | Roberto Cofresi SC 0 |
Oeste,
Puerto Rico
Puerto Rico
